Anti-Human/Mouse/Rat FNK Polyclonal Antibody

Cytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory domain. It may play a role in regulation of cell cycle progression and tumorigenesis. Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA12700
Size 100μl
Host Type Rabbit
Immunogen Recombinant protein of human PLK3
Specificity Transcripts are highly detected in placenta, lung, followed by skeletal muscle, heart, pancreas, ovaries and kidney and weakly detected in liver and brain. May have a short half-live. In cells of hematopoietic origin, strongly and exclusively detected in terminally differentiated macrophages. Transcript expression appears to be down-regulated in primary lung tumor.
Isotype IgG
Reacitivity Human,Mouse,Rat
Clone
Uniprot Q9H4B4
Concentration 0.2 mg/mL
Dilution IHC 1:50-1:200
Formulation
Application IHC,ELISA
Other Names CNK,Cytokine Inducible Kinase,Cytokine-inducible serine/threonine-protein kinase,FGF inducible kinase,FGF-inducible kinase,FNK,PLK-3,Plk3,PLK3,Polo Like Kinase 3,Polo-like kinase 3,PRK,Proliferation Related Kinase,Proliferation-related kinase,Serine/threonine-protein kinase PLK3
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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