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Anti-Human/Mouse/Rat EPCAM Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. EpCAM is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signalling and polarity. It has been used as an immunotherapeutic target in the treatment of gastrointestinal, urological and other carcinomas. It is expressed in undifferentiated pluripotent stem cells.tufting enteropathy.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA11319
Size 100μl
Host Type Rabbit
Immunogen Synthetic peptide of human EPCAM
Specificity Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma.
Isotype IgG
Reacitivity Human,Mouse,Rat
Clone
Uniprot P16422
Concentration 0.3 mg/mL
Dilution IHC 1:50-1:200
Formulation
Application IHC,ELISA
Other Names 17 1A,323/A3,Adenocarcinoma associated antigen,Adenocarcinoma-associated antigen,Antigen identified by monoclonal AUA1,AUA1,CD326,CD326 antigen,Cell surface glycoprotein Trop 1,Cell surface glycoprotein Trop 2,Cell surface glycoprotein Trop-1,CO 17A,CO17 1A,CO17A,DIAR5,EGP 2,EGP,EGP2,EGP314,EGP40,Ep CAM,Ep-CAM,EPCAM,EPCAM,EpCAM1,Epithelial cell adhesion molecule,Epithelial Cell Adhesion Molecule Intracellular Domain (EpCAM-ICD),Epithelial cell surface antigen,Epithelial cellular adhesion molecule,Epithelial glycoprotein 1,Epithelial glycoprotein 314,Epithelial glycoprotein,ESA,GA733 1,GA733 2,GA733-2,gastrointestinal tumor-associated antigen 2,35-KD glycoprotein,gp4,hEGP 2,hEGP314,HNPCC8,Human epithelial glycoprotein 2,KS 1/4 antigen,KS1/4,KSA,Ly74,Lymphocyte antigen 74,M1S 1,M1S2,M4S1,Major gastrointestinal tumor associated protein GA733 2,Major gastrointestinal tumor-associated protein GA733-2,mEGP314,Membrane component chromosome 4 surface marker (35kD glycoprotein),Membrane component,chromosome 4,surface marker 1,Membrane component,chromosome 4,surface marker,MIC18,MK 1,Protein 289A,TACD1,TACSTD1,TROP1,Tumor associated calcium signal transducer 1,Tumor associated calcium signal transducer 2 precursor,Tumor-associated calcium signal transducer 1
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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