Anti-Human/Mouse/Rat EGLN1 Polyclonal Antibody

The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA10239
Size 100μl
Host Type Rabbit
Immunogen Recombinant protein of human EGLN1
Specificity According to PubMed:11056053, widely expressed with highest levels in skeletal muscle and heart, moderate levels in pancreas, brain (dopaminergic neurons of adult and fetal substantia nigra) and kidney, and lower levels in lung and liver. According to PubMed:12351678 widely expressed with highest levels in brain, kidney and adrenal gland. Expressed in cardiac myocytes, aortic endothelial cells and coronary artery smooth muscle.
Isotype IgG
Reacitivity Human,Mouse,Rat
Clone
Uniprot Q9GZT9
Concentration 0.9 mg/mL
Dilution IHC 1:25-1:100
Formulation
Application IHC,ELISA
Other Names C1ORF12,Chromosome 1 Open Reading Frame 12,DKFZp761F179,ECYT 3,ECYT3,Egl 9 family hypoxia inducible factor 1,EGL 9 homolog of C. elegans 1,EGL nine (C.elegans) homolog 1,Egl nine homolog 1 (C. elegans),Egl nine homolog 1,Egl nine like protein 1,EGLN 1,Egln1,EGLN1,HIF PH2,HIF Prolyl Hydroxylase 2,HIF-PH2,HIF-prolyl hydroxylase 2,HIFP4H 2,HIFPH2,HPH 2,HPH-2,HPH2,Hypoxia inducible factor prolyl hydroxylase 2,Hypoxia-inducible factor prolyl hydroxylase 2,ORF13,P4H2,PHD 2,PhD2,PNAS 118,PNAS 137,Prolyl Hydroxylase Domain Containing Protein 2,Prolyl hydroxylase domain-containing protein 2,Rat Homolog of SM20,SM 20,SM-20,SM20,Zinc finger MYND domain containing protein 6,ZMYND6
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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