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Anti-Human/Mouse/Rat DMBT1 Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor suppressor gene, but rather play a role in the interaction of tumor cells and the immune system.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA07388
Size 100μl
Host Type Rabbit
Immunogen Synthetic peptide of human DMBT1
Specificity Highly expressed in alveolar and macrophage tissues. In some macrophages, expression is seen on the membrane, and in other macrophages, strongly expressed in the phagosome/phagolysosome compartments. Expressed in lung, trachea, salivary gland, small intestine and stomach. In pancreas, expressed in certain cells of the islets of Langerhans. In digestive tract, confined to tissues with large epithelial surfaces. In intestinal tissue, moderately expressed in epithelial cells of the midcrypts and the crypt base. Expression is significantly elevated in intestinal tissue from patients with inflammatory bowel disease (IBD), particularly in surface epithelial and Paneth cells, but not in IBD patients with mutant NOD2. Present in crypt bases of the duodenum, in crypt tops of the colon, and in collecting ducts of the cortical kidney. Expressed in stratified squamous epithelium of vagina and in outer luminar surface and basilar region of columnar epithelial cells in cervix (at protein level). Isoform 1 is secreted to the lumen of the respiratory tract.
Isotype IgG
Reacitivity Human,Mouse,Rat
Clone
Uniprot Q9UGM3
Concentration 0.3 mg/mL
Dilution IHC 1:10-50, ELISA 1:1000-2000
Formulation
Application IHC,ELISA
Other Names Apactin,CRP,CRP-[a],CRP-[b],CRP-ductin,Crpd,DBMT1,Deleted in malignant brain tumors 1,Deleted in malignant brain tumors 1 protein,DMBT 1,DMBT1,DMBT1 prototype precursor,DMBT1/6kb.1 protein precursor,DMBT1/8kb.1 protein,DMBT1/8kb.2 protein precursor,DMBT1,Ebnerin,FLJ61058,Glycoprotein 300,Glycoprotein 340,Gp 340,Gp-340,gp300,GP340,Gp340 variant protein,Hensin,MGC164738,Mucin-like glycoprotein,Muclin,OTTHUMP00000020654,OTTHUMP00000020655,OTTHUMP00000020656,OTTHUMP00000020657,OTTHUMP00000020658,OTTHUMP00000020659,OTTHUMP00000020660,OTTHUMP00000020661,OTTHUMP00000020662,OTTHUMP00000020663,p80,Pancrin,SAG,Salivary agglutinin,Surfactant pulmonary associated D binding protein,Surfactant pulmonary associated protein D binding protein,Surfactant pulmonary-associated D-binding protein,Vomeroglandin
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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