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Anti-Human/Mouse/Rat DHCR24 Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA10500
Size 100μl
Host Type Rabbit
Immunogen Recombinant protein of human DHCR24
Specificity Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. Undetectable in blood cells. In the brain, strongly expressed in cortical regions, substantia nigra, caudate nucleus, hippocampus, medulla oblongata and pons. In brains affected by Alzheimer disease, expression in the inferior temporal lobe is substantially lower than in the frontal cortex.
Isotype IgG
Reacitivity Human,Mouse,Rat
Clone
Uniprot Q15392
Concentration 0.6 mg/mL
Dilution IHC 1:25-1:100
Formulation
Application IHC,ELISA
Other Names 24 dehydrocholesterol reductase,24-dehydrocholesterol reductase,3 beta hydroxysterol delta 24 reductase,3-beta-hydroxysterol delta-24-reductase,DCE,Delta(24)-sterol reductase,Desmosterol to cholesterol enzyme,DHC24,Dhcr24,Diminuto dwarf1 homolog,Diminuto/dwarf1 homolog,KIAA0018,Nbla03646,Seladin-1,SELADIN1,Selective AD indicator 1,Selective Alzheimer's Disease Indicator 1
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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