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Anti-Human/Mouse/Rat DCX Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
Seems to be required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCAMKL1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with LIS-1 of an overlapping, but distinct, signaling pathways that promote neuronal migration.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA03579
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from human Doublecortin around the non-phosphorylation site of S376.
Specificity Highly expressed in neuronal cells of fetal brain (in the majority of cells of the cortical plate, intermediate zone and ventricular zone), but not expressed in other fetal tissues. In the adult, highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas.
Isotype IgG
Reacitivity Human,Mouse,Rat
Clone
Uniprot O43602
Concentration 1mg/mL
Dilution WB 1:500-1:2000, ELISA 1:10000
Formulation
Application WB,ELISA
Other Names DBCN,Dbct,DC,DCX,DCX,Doublecortex,Doublin,FLJ51296,Lis X,Lis-X,Lissencephalin X,Lissencephalin-X,Lissencephaly X linked,Lissencephaly X linked doublecortin,LISX,Neuronal migration protein doublecortin,OTTHUMP00000023859,OTTHUMP00000023860,OTTHUMP00000216315,OTTHUMP00000216316,SCLH,XLIS
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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