Anti-Human/Mouse/Rat CDC73 Polyclonal Antibody

This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma. CDC73 (Cell Division Cycle 73) is a Protein Coding gene. Diseases associated with CDC73 include Hyperparathyroidism-Jaw Tumor Syndrome and Parathyroid Carcinoma. Among its related pathways are Signaling by Wnt and Signaling by Hedgehog. GO annotations related to this gene include RNA polymerase II core binding.