Anti-Human/Mouse/Rat CD42c Polyclonal Antibody

GP1BB (Glycoprotein Ib Platelet Beta Subunit) is a Protein Coding gene. Diseases associated with GP1BB include Bernard-Soulier Syndrome, Type C and Velocardiofacial Syndrome. Among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Response to elevated platelet cytosolic Ca2+. GO annotations related to this gene include transmembrane signaling receptor activity. An important paralog of this gene is GP9.Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain.