Anti-Human/Mouse/Rat CASP2 Polyclonal Antibody

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA11399
Size 100μl
Host Type Rabbit
Immunogen Recombinant protein of human CASP2
Specificity Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle.
Isotype IgG
Reacitivity Human,Mouse,Rat
Clone
Uniprot P42575
Concentration 0.6 mg/mL
Dilution WB 1:1000-1:2000, IHC 1:100-1:300
Formulation
Application WB,IHC,ELISA
Other Names CASP 2,CASP-2,Casp2,CASP2,Caspase 2,Caspase 2 apoptosis related cysteine peptidase,Caspase-2 subunit p12,Caspase2,ICH 1,ICH 1 protease,ICH 1L,ICH1,ICH1 protease,ICH1L,NEDD-2,NEDD2,Neural precursor cell expressed developmentally down-regulated protein 2,PPP1R57,Protease ICH-1,Protein phosphatase 1 regulatory subunit 57
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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