Anti-Human /Mouse /Rat CAMK2N2 Polyclonal Antibody

This gene encodes a protein that is highly similar to the rat CaM-KII inhibitory protein, an inhibitor of calcium/calmodulin-dependent protein kinase II (CAMKII). CAMKII regulates numerous physiological functions, including neuronal synaptic plasticity through the phosphorylation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate (AMPA) receptors. Studies of the similar protein in rat suggest that this protein may function as a negative regulator of CaM-KII and may act to inhibit the phosphorylation of AMPA receptors. CAMK2N2 (Calcium/Calmodulin Dependent Protein Kinase II Inhibitor 2) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding and calcium-dependent protein kinase inhibitor activity. An important paralog of this gene is CAMK2N1.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA03384
Size 100μl
Host Type Rabbit
Immunogen Synthetic peptide of human CAMK2N2 (Ab-286)
Specificity Expressed in cell lines including hemopoietic cell lines and some tumor cell lines. Highly Expressed in stimulated dendritic cell (DC) and weakly expressed in unstimulated mature and immature DC. Highly expressed in kidney, liver, in cell lines HeLaS3, lymphoblastic leukemia MOLT-4, and Burkitt's lymphoma Raji. Moderately expressed in heart, skeletal muscle, placenta, and chronic myelogenous leukemia K-562 cells. Weakly expressed in small intestine, colorectal adenocarcinoma SW480, and lung carcinoma A-549 cells.
Isotype IgG
Reacitivity Human ,Mouse ,Rat
Clone
Uniprot Q96S95
Concentration 1 mg/mL
Dilution WB 1:500-1:1000, IF/ICC 1:100-1:200
Formulation
Application WB,IF
Other Names CAMKIIN,CAM-KIIN
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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