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Anti-Human/Mouse/Rat AURKB Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
May be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Phosphorylates 'Ser-10' and 'Ser-28' of histone H3 during mitosis. Required for kinetochore localization of BUB1 and SGOL1. Interacts with INCENP.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA02090
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from human ARK-2 around the non-phosphorylation site of Tyr12.
Specificity High level expression seen in the thymus. It is also expressed in the spleen, lung, testis, colon, placenta and fetal liver. Expressed during S and G2/M phase and expression is up-regulated in cancer cells during M phase.
Isotype IgG
Reacitivity Human,Mouse,Rat
Clone
Uniprot Q96GD4
Concentration 1mg/mL
Dilution WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:40000
Formulation
Application WB,IHC-p,IF,ELISA
Other Names AIK2,AIM-1,AIM1,ARK-2,ARK2,AurB,AURKB,AURKB,Aurora 1,Aurora and Ipl1 like midbody associated protein 1,Aurora kinase B,Aurora related kinase 2,Aurora- and Ipl1-like midbody-associated protein 1,Aurora-B,Aurora-related kinase 2,Aurora/IPL1 related kinase 2,Aurora/IPL1-related kinase 2,IPL1,PPP1R48,Protein phosphatase 1 regulatory subunit 48,Serine/theronine kinase 12,Serine/threonine protein kinase 12,Serine/threonine-protein kinase 12,Serine/threonine-protein kinase aurora-B,STK-1,STK1,STK12,STK5
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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