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Anti-Human /Mouse /Rat AKR1C3 Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA03228
Size 100μl
Host Type Rabbit
Immunogen Recombinant protein of human AKR1C3
Specificity Expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. The dominant HSD in prostate and mammary gland. In the prostate, higher levels in epithelial cells than in stromal cells. In the brain, expressed in medulla, spinal cord, frontotemporal lobes, thalamus, subthalamic nuclei and amygdala. Weaker expression in the hippocampus, substantia nigra and caudate.
Isotype IgG
Reacitivity Human ,Mouse ,Rat
Clone
Uniprot P42330
Concentration 0.7 mg/mL
Dilution WB 1:500-1:2000
Formulation
Application WB
Other Names 17 beta HSD 5,17 beta hydroxysteroid dehydrogenase type 5,17-beta-HSD 5,17-beta-hydroxysteroid dehydrogenase type 5,2-dihydrobenzene-1,2-diol dehydrogenase,20-alpha-hydroxysteroid dehydrogenase,3 alpha hydroxysteroid dehydrogenase type II,3-alpha-HSD type 2,3-alpha-HSD type II,3-alpha-HSD type II,brain,3-alpha-hydroxysteroid dehydrogenase type 2,AK1C3,AKR1 C3,Akr1c18,AKR1C3,Aldo keto reductase family 1 member C3,Aldo-keto reductase family 1 member C3,brain,Chlordecone reductase,Chlordecone reductase homolog HAKRb,DD-3,DD3,DDH1,DDX,Dihydrodiol dehydrogenase 3,Dihydrodiol dehydrogenase type I,Dihydrodiol dehydrogenase X,HA1753,HAKRB,HAKRe,hluPGFS,HSD17B5,Indanol dehydrogenase,KIAA0119,PGFS,Prostaglandin F synthase,Testosterone 17-beta-dehydrogenase 5,Trans-1,Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase,Type IIb 3 alpha hydroxysteroid dehydrogenase
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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