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Anti-Human/Mouse/Rat AIFM1 Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. 
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Properties

Data Sheet Click for Datasheet
Catalog Number PA11537
Size 100μl
Host Type Rabbit
Immunogen Recombinant protein of human AIFM1
Specificity Detected in muscle and skin fibroblasts (at protein level). Isoform 5 is frequently down-regulated in human cancers.
Isotype IgG
Reacitivity Human,Mouse,Rat
Clone
Uniprot O95831
Concentration 0.3 mg/mL
Dilution WB 1:200-1:1000, IHC 1:15-1:50
Formulation
Application WB,IHC,ELISA
Other Names AIFM1,AIFM1,Apoptosis inducing factor 1,mitochondrial,Apoptosis inducing factor,Apoptosis inducing factor,mitochondrion associated,1,Apoptosis-inducing factor 1,CMTX4,COWCK,COXPD6,Harlequin,Hq,mAIF,MGC111425,MGC5706,mitochondrial,Neuropathy,axonal motor-sensory,with deafness and mental retardation,neuropathy,axonal,motor-sensory with deafness and mental retardation (Cowchock syndrome),PDCD 8,PDCD8,Programmed cell death 8 (apoptosis inducing factor),Programmed cell death 8,Programmed cell death 8 isoform 1,Programmed cell death 8 isoform 2,Programmed cell death 8 isoform 3,Programmed cell death protein 8,Programmed cell death protein 8 mitochondrial,Programmed cell death protein 8 mitochondrial precursor,Programmed cell death protein 8 mitochondrial precursor,Striatal apoptosis inducing factor
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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