Anti-Human/Mouse/Rat Acetyl-Histone H2B (Lys126) Polyclonal Antibody

The nucleosome, made up of four core histone proteins (H2A, H2B, H3, and H4), is the primary building block of chromatin. Originally thought to function as a static scaffold for DNA packaging, histones have now been shown to be dynamic proteins, undergoing multiple types of post-translational modifications, including acetylation, phosphorylation, methylation, and ubiquitination , acetylation of specific lysine residues creates docking sites that facilitate recruitment of many transcription and chromatin regulatory proteins that contain a bromodomain, which binds to acetylated lysine residues . Histone H2B is rapidly phosphorylated at irradiation-induced DNA damage foci in mouse embryonic fibroblasts .
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Properties

Data Sheet Click for Datasheet
Catalog Number PA01421
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from the human Histone H2B around the acetylation site of K126.
Specificity Mainly expressed in testis, and the corresponding protein is also present in mature sperm (at protein level). Also found in some fat cells.
Isotype IgG
Reacitivity Human,Mouse,Rat
Clone
Uniprot Q96A08
Concentration 1mg/mL
Dilution WB 1:500-1:2000, ELISA 1:20000
Formulation
Application WB,ELISA
Other Names HIST1H2BA,testis,bA317E16.3,H2B,H2B histone family member U,H2B histone family member U testis specific,H2B histone family,member U,(testis specific),H2B testis,H2B1A,H2BFU,H2BT,HIST1H2BA,Histone 1,H2ba,Histone cluster 1 H2ba,Histone H2B,Histone H2B testis,Histone H2B type 1 A,Histone H2B type 1-A,Histone H2B type 1A,STBP,Testis specific histone H2B,Testis-specific histone H2B,TSH 2B,TSH2B,TSH2B.1
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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