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Anti-Human/Mouse PSCA Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
PSCA (Prostate Stem Cell antigen) is a cell surface antigen, which is overexpressed in ~40% of primary prostate cancers and in as many as 100% of metastatic ones. PSCA is also overexpressed in a majority of transitional cell and pancreatic carcinomas. Antibody directed against PSCA inhibits tumorigenesis, slows tumor growth, prolongs survival and prevents metastasis in a preclinical zenograft model indicating that PSCA may have utility as a prognostic marker and/or therapeutic target in prostate cancer.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA05637
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from the Internal region of human PSCA
Specificity Highly expressed in prostate (basal, secretory and neuroendocrine epithelium cells). Also found in bladder (transitional epithelium), placenta (trophoblasts), stomach (neuroendocrine cells), colon (neuroendocrine cells) and kidney (collecting ducts). Overexpressed in prostate cancers and expression is correlated with tumor stage, grade and androgen-independence. Highly expressed in prostate cancer bone metastases. Expressed in gastric epithelial cells, mainly in the isthmus (at protein level). Not detected in normal intestinal epithelium (at protein level). Expressed in brain cortex; expression is significantly increased in the front cortex of Alzheimer disease patients.
Isotype IgG
Reacitivity Human,Mouse
Clone
Uniprot O43653
Concentration 1mg/mL
Dilution WB 1:500-1:2000, ELISA 1:20000
Formulation
Application WB,ELISA
Other Names PRO 232,PRO232,Prostate stem cell antigen
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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