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Anti-Human/Mouse Phospho-TEK (Tyr992) Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smootHuman, Mouseuscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA01703
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from human Tie-2 around the phosphorylation site of Tyr992
Specificity Detected in umbilical vein endothelial cells. Proteolytic processing gives rise to a soluble extracellular domain that is detected in blood plasma (at protein level). Predominantly expressed in endothelial cells and their progenitors, the angioblasts. Has been directly found in placenta and lung, with a lower level in umbilical vein endothelial cells, brain and kidney.
Isotype IgG
Reacitivity Human,Mouse
Clone
Uniprot Q02763
Concentration 1mg/mL
Dilution WB 1:500-1:2000, ELISA 1:10000
Formulation
Application WB,ELISA
Other Names Angiopoietin 1 receptor,Angiopoietin-1 receptor,CD202b,CD202b antigen,Endothelial tyrosine kinase,Endothelium specific receptor tyrosine kinase 2,hTIE 2,hTIE2,Hyk,p140 TEK,Soluble TIE2 variant 1,Soluble TIE2 variant 2,Tek,tek tyrosine kinase,TEK tyrosine kinase endothelial,tek tyrosine kinase,endothelial,TIE 2,TIE2,TIE2,Tunica interna endothelial cell kinase,Tyrosine kinase with Ig and EGF homology domains 2,Tyrosine kinase with Ig and EGF homology domains-2,Tyrosine protein kinase receptor TEK,Tyrosine protein kinase receptor TIE 2,Tyrosine-protein kinase receptor TEK,Tyrosine-protein kinase receptor TIE-2,Venous malformations multiple cutaneous and mucosal,VMCM 1,VMCM,VMCM1
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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