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Anti-Human/Mouse Phospho-RPS6KA5 (Ser376) Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).
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Properties

Data Sheet Click for Datasheet
Catalog Number PA01728
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from human MSK1 around the phosphorylation site of Ser376
Specificity Widely expressed with high levels in heart, brain and placenta. Less abundant in lung, kidney and liver.
Isotype IgG
Reacitivity Human,Mouse
Clone
Uniprot O75582
Concentration 1mg/mL
Dilution WB 1:500-1:2000, IF 1:100-1:300, ELISA 1:20000
Formulation
Application WB,IF,ELISA
Other Names 90 kDa ribosomal protein S6 kinase 5,EC 2.7.11.1,KS6A5,MGC1911,Mitogen and stress activated protein kinase 1,MSPK1,Nuclear Mitogen And Stress Activated Protein Kinase 1,Nuclear mitogen- and stress-activated protein kinase 1,Ribosomal protein S6 kinase 90kD polypeptide 5,Ribosomal protein S6 kinase 90kDa,Ribosomal protein S6 kinase 90kDa polypeptide 5,Ribosomal Protein S6 Kinase Alpha 5,Ribosomal protein S6 kinase alpha-5,RLPK,RPS6KA5,RSK Like Protein Kinase,RSK-like protein kinase,RSKL,S6K alpha 5,S6K-alpha-5
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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