Anti-Human/Mouse ECE2 Polyclonal Antibody

This gene encodes a member of the M13 family, which includes type 2 integral membrane metallopeptidases. The encoded enzyme is a membrane-bound zinc-dependent metalloprotease. The enzyme catalyzes the cleavage of big endothelin to produce the vasoconstrictor endothelin-1, and plays a role in the processing of several neuroendocrine peptides. It may also have methyltransferase activity. Alternative splicing results in multiple transcript variants. 
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Properties

Data Sheet Click for Datasheet
Catalog Number PA07699
Size 100μl
Host Type Rabbit
Immunogen Fusion protein of human ECE2
Specificity Expressed in brain. Strongly down-regulated in inferior parietal lobe from Alzheimer disease patients (at protein level).
Isotype IgG
Reacitivity Human,Mouse
Clone
Uniprot O60344
Concentration 0.3 mg/mL
Dilution WB 1:200-1000, IHC 1:25-100, ELISA 1:1000-2000
Formulation
Application WB,IHC,ELISA
Other Names ECE 2,ECE-2,ECE2,ECE2,Endothelin converting enzyme 2,Endothelin-converting enzyme 2 region,Hypothetical protein MGC2408,KIAA0604,MGC17664,MGC78487
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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