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Anti-Human/Mouse CD133 Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene. 
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Properties

Data Sheet Click for Datasheet
Catalog Number PA09797
Size 100μl
Host Type Rabbit
Immunogen Synthetic peptide of human PROM1
Specificity Isoform 1 is selectively expressed on CD34 hematopoietic stem and progenitor cells in adult and fetal bone marrow, fetal liver, cord blood and adult peripheral blood. Isoform 1 is not detected on other blood cells. Isoform 1 is also expressed in a number of non-lymphoid tissues including retina, pancreas, placenta, kidney, liver, lung, brain and heart. Found in saliva within small membrane particles. Isoform 2 is predominantly expressed in fetal liver, skeletal muscle, kidney, and heart as well as adult pancreas, kidney, liver, lung, and placenta. Isoform 2 is highly expressed in fetal liver, low in bone marrow, and barely detectable in peripheral blood. Isoform 2 is expressed on hematopoietic stem cells and in epidermal basal cells (at protein level). Expressed in adult retina by rod and cone photoreceptor cells (at protein level).
Isotype IgG
Reacitivity Human,Mouse
Clone
Uniprot O43490
Concentration 0.4 mg/mL
Dilution IHC 1:50-1:200
Formulation
Application IHC,ELISA
Other Names AC133,Antigen AC133,CD133,CORD12,Hematopoietic stem cell antigen,hProminin,MCDR2,MSTP061,OTTHUMP00000217744,OTTHUMP00000217745,OTTHUMP00000217746,PROM1,PROM1,Prominin I,Prominin like 1,Prominin like protein 1 precursor,Prominin mouse like 1,Prominin-1,Prominin-like protein 1,Prominin1,PROML1,RP41,STGD4
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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