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Anti-Human LIN28B Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation. [provided by RefSeq, Jun 2012]
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Properties

Data Sheet Click for Datasheet
Catalog Number PA09897
Size 100μl
Host Type Rabbit
Immunogen Synthetic peptide of human LIN28B
Specificity High expression in testis, fetal liver, placenta and in hepatocellular carcinoma (HCC). Isoform 1 is only detected in moderately and poorly differentiated HCC tissues and placenta (at protein level). Isoform 2 is detected in fetal liver, non-tumor liver tissues, as well as well-differentiated tumor tissues (at protein level).
Isotype IgG
Reacitivity Human
Clone
Uniprot Q6ZN17
Concentration 0.3 mg/mL
Dilution WB 1:500-1:2000
Formulation
Application WB,ELISA
Other Names CSDD 2,CSDD2,FLJ16517,Lin 28 homolog B (C. elegans),Lin 28.2,Lin-28B,LIN28B,LN28B,Protein lin-28 homolog B
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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