Anti-Human KISS1R Polyclonal Antibody

The protein encoded by this gene is a galanin-like G protein-coupled receptor that binds metastin, a peptide encoded by the metastasis suppressor gene KISS1. The tissue distribution of the expressed gene suggests that it is involved in the regulation of endocrine function, and this is supported by the finding that this gene appears to play a role in the onset of puberty. Mutations in this gene have been associated with hypogonadotropic hypogonadism and central precocious puberty.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA10285
Size 100μl
Host Type Rabbit
Immunogen Synthetic peptide of human KISS1R
Specificity Most highly expressed in the pancreas, placenta and spinal cord, with lower-level of expression in peripheral blood leukocytes, kidney, lung, fetal liver, stomach, small intestine, testes, spleen, thymus, adrenal glands and lymph nodes. In the adult brain, expressed in the superior frontal gyrus, putamen, caudate nucleus, cingulate gyrus, nucleus accumbens, hippocampus, pons and amygdala, as well as the hypothalamus and pituitary. Expression levels are higher in early (7-9 weeks) than term placentas. Expression levels were increased in both early placentas and molar pregnancies and were reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation. Also found in the extravillous trophoblast suggesting endocrine/paracrine activation mechanism.
Isotype IgG
Reacitivity Human
Clone
Uniprot Q969F8
Concentration #N/A
Dilution IHC 1:50-1:200
Formulation
Application IHC,ELISA
Other Names AXOR 12,AXOR12,G protein coupled receptor 54,G-protein coupled receptor 54,G-protein coupled receptor OT7T175,GPCR 54,GPCR54,GPR 54,GPR54,hOT7T175,Hypogonadotropin 1,Hypogonadotropin-1,Hypogonadotropin1,KISS 1 receptor,KISS 1R,KiSS-1 receptor,KiSS-1R,KISS1 receptor,Kiss1r,Kisspeptins receptor,KISSR,Metastin receptor,OT7T175
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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