Anti-Human Insulin R Polyclonal Antibody

Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling interme
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Properties

Data Sheet Click for Datasheet
Catalog Number PA04990
Size 100μl
Host Type Rabbit
Immunogen Synthetic peptide from human protein
Specificity Isoform Long and isoform Short are predominantly expressed in tissue targets of insulin metabolic effects: liver, adipose tissue and skeletal muscle but are also expressed in the peripheral nerve, kidney, pulmonary alveoli, pancreatic acini, placenta vascular endothelium, fibroblasts, monocytes, granulocytes, erythrocytes and skin. Isoform Short is preferentially expressed in fetal cells such as fetal fibroblasts, muscle, liver and kidney. Found as a hybrid receptor with IGF1R in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Overexpressed in several tumors, including breast, colon, lung, ovary, and thyroid carcinomas.
Isotype IgG
Reacitivity Human
Clone
Uniprot P06213
Concentration 1mg/mL
Dilution IHC 1:50-200, ELISA 1:10000-20000
Formulation
Application IHC-p,ELISA
Other Names CD220,HHF5,human insulin receptor,Insr,INSR,Insulin receptor subunit beta,IR 1,IR,IR-1,IR1
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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