Anti-Human EIF2AK2 Polyclonal Antibody

The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene
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Properties

Data Sheet Click for Datasheet
Catalog Number PA10261
Size 100μl
Host Type Rabbit
Immunogen Synthetic peptide of human EIF2AK2
Specificity Highly expressed in thymus, spleen and bone marrow compared to non-hematopoietic tissues such as small intestine, liver, or kidney tissues. Colocalizes with GSK3B and TAU in the Alzheimer disease (AD) brain. Elevated levels seen in breast and colon carcinomas,and which correlates with tumor progression and invasiveness or risk of progression.
Isotype IgG
Reacitivity Human
Clone
Uniprot P19525
Concentration 0.5 mg/mL
Dilution IHC 1:50-1:200
Formulation
Application IHC,ELISA
Other Names Double stranded RNA activated protein kinase;,E2AK2,eIF-2A protein kinase 2,EIF2AK1,EIF2AK2,Eukaryotic translation initiation factor 2 alpha kinase 2,Eukaryotic translation initiation factor 2-alpha kinase 2,HGNC:9437,Interferon induced double stranded RNA activated protein kinase,Interferon inducible elF2 alpha kinase,Interferon inducible RNA dependent protein kinase,Interferon-induced,double-stranded RNA-activated protein kinase,Interferon-inducible RNA-dependent protein kinase,MGC126524,P1/eIF-2A protein kinase,P1/eIF2A protein kinase,p68 kinase,PKR,PPP1R83,PRKR,Protein kinase interferon inducible double stranded RNA dependent,Protein kinase RNA activated,Protein kinase RNA-activated,Protein phosphatase 1 regulatory subunit 83,Serine/threonine protein kinase TIK,Tyrosine protein kinase EIF2AK2
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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