Anti-Human ECE2 Polyclonal Antibody

Endothelin-converting enzymes, such as ECE2 (EC 3.4.24.71), are type II metalloproteases that generate functionally pleiotropic members of the endothelin vasoactive peptide family. It converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta-amyloid peptide accumulation in brain. May also have methyltransferase activity.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA12146
Size 100μl
Host Type Rabbit
Immunogen Recombinant protein of human ECE2
Specificity Expressed in brain. Strongly down-regulated in inferior parietal lobe from Alzheimer disease patients (at protein level).
Isotype IgG
Reacitivity Human
Clone
Uniprot O60344
Concentration 0.1 mg/mL
Dilution IHC 1:50-1:200
Formulation
Application IHC,ELISA
Other Names ECE 2,ECE-2,ECE2,ECE2,Endothelin converting enzyme 2,Endothelin-converting enzyme 2 region,Hypothetical protein MGC2408,KIAA0604,MGC17664,MGC78487
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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