Anti-Human DMPK Polyclonal Antibody

The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-38 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.DMPK (Dystrophia Myotonica Protein Kinase) is a Protein Coding gene. Diseases associated with DMPK include Myotonic Dystrophy 1 and Myotonic Dystrophy. Among its related pathways are Cardiac conduction and G-protein signaling RAC1 in cellular process. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDC42BPB.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA03535
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from the N-terminal region of human DMPK
Specificity Most isoforms are expressed in many tissues including heart, skeletal muscle, liver and brain, except for isoform 2 which is only found in the heart and skeletal muscle, and isoform 14 which is only found in the brain, with high levels in the striatum, cerebellar cortex and pons.
Isotype IgG
Reacitivity Human
Clone
Uniprot Q09013
Concentration 1mg/mL
Dilution WB 1:500-1:2000, ELISA 1:40000
Formulation
Application WB,ELISA
Other Names DM 1,DM,DM kinase,DM protein kinase,DM-kinase,DM1,DM1 protein kinase,DM1PK,DMK,DMPK,DMPK,Dystrophia myotonica 1,Dystrophia myotonica protein kinase,MDPK,MT PK,MT-PK,Myotonic dystrophy associated protein kinase,Myotonic dystrophy protein kinase,Myotonin protein kinase A,Myotonin protein kinase,Myotonin-protein kinase,Thymopoietin homolog
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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