Anti-Human DHH Polyclonal Antibody

This gene encodes a member of the hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA09812
Size 200μl
Host Type Rabbit
Immunogen Synthetic peptide of human DHH
Specificity
Isotype IgG
Reacitivity Human
Clone
Uniprot O43323
Concentration 1.2 mg/mL
Dilution IHC 1:50-1:200
Formulation
Application IHC,ELISA
Other Names C78960,Desert hedgehog (Drosophila) homolog,Desert hedgehog,Desert hedgehog homolog (Drosophila),Desert hedgehog protein C-product,Desert hedgehog protein precursor,DHH,DHH,GDXYM,HHG-3,Hira,SRXY7
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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