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Anti-Human CYP3A4 Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. The enzyme also hydroxylates etoposide.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA03410
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from the Internal region of human CYP3A4
Specificity Expressed in prostate and liver. According to some authors, it is not expressed in brain (PubMed:19094056). According to others, weak levels of expression are measured in some brain locations (PubMed:19359404 and PubMed:18545703). Also expressed in epithelium of the small intestine and large intestine, bile duct, nasal mucosa, kidney, adrenal cortex, epithelium of the gastric mucosa with intestinal metaplasia, gallbladder, intercalated ducts of the pancreas, chief cells of the parathyroid and the corpus luteum of the ovary (at protein level).
Isotype IgG
Reacitivity Human
Clone
Uniprot P08684
Concentration 1mg/mL
Dilution WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:5000
Formulation
Application WB,IHC-p,ELISA
Other Names 1,8-cineole 2-exo-monooxygenase,Albendazole monooxygenase,Albendazole sulfoxidase,CP33,CP34,CP3A4,CYP3,CYP3A,CYP3A3,CYP3A4,CYPIIIA3,CYPIIIA4,Cytochrome P450 3A3,Cytochrome P450 3A4,Cytochrome P450 family 3 subfamily A polypeptide 4,Cytochrome P450 HLp,Cytochrome P450 NF-25,Cytochrome P450 subfamily IIIA polypeptide 4,cytochrome P450,subfamily IIIA (niphedipine oxidase),polypeptide 3,cytochrome P450,subfamily IIIA (niphedipine oxidase),polypeptide 4,Cytochrome P450-PCN1,Glucocorticoid inducible P450,HLP,MGC126680,NF 25,NF25,Nifedipine oxidase,P450 III steroid inducible,P450 PCN1,P450,family III,P450C3,P450PCN1,Quinine 3 monooxygenase,Quinine 3-monooxygenase,Taurochenodeoxycholate 6 alpha hydroxylase,Taurochenodeoxycholate 6-alpha-hydroxylase
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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