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Anti-Human CRTAM Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains. Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA11984
Size 100μl
Host Type Rabbit
Immunogen Recombinant protein of human CRTAM
Specificity In the immune system, expression is restricted to activated class-I MHC-restricted cells, including NKT and CD8 cells. Strongly expressed in spleen, thymus, small intestine, peripheral blood leukocyte, and in Purkinje neurons in cerebellum. Expressed at much lower levels in testis, ovary, colon, lung and lymphoid tissues.
Isotype IgG
Reacitivity Human
Clone
Uniprot O95727
Concentration 0.2 mg/mL
Dilution IHC 1:25-1:100
Formulation
Application IHC,ELISA
Other Names CD355,Class I MHC restricted T cell associated molecule,Class-I MHC-restricted T-cell-associated molecule,CRTAM,CRTAM,Cytotoxic and regulatory T cell molecule,Cytotoxic and regulatory T-cell molecule
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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