Anti-Human Cleaved-KNG1 HC (K380) Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]

This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.

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Properties

Data Sheet	Click for Datasheet
Catalog Number	PA02182
Size	100μl
Host Type	Rabbit
Immunogen	Synthesized peptide derived from the Internal region of human Kininogen-1 HC
Specificity	Secreted in plasma. T-kinin is detected in malignant ovarian, colon and breast carcinomas, but not in benign tumors.
Isotype	IgG
Reacitivity	Human
Clone
Uniprot	P01042
Concentration	1mg/mL
Dilution	WB 1:500-1:2000, ELISA 1:10000
Formulation
Application	WB,ELISA
Other Names	Alpha-2-thiol proteinase inhibitor,BDK,BK,Fitzgerald factor,High molecular weight kininogen,HMWK,Ile-Ser-Bradykinin,Kallidin I,Kallidin II,Kininogen 1,KNG,KNG1,KNG1,LMW,Low molecular weight growth-promoting factor,Low molecular weight kininogen,Williams-Fitzgerald-Flaujeac factor
Storage	Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript	For research use only, not for use in diagnostic procedures.

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Anti-Human Cleaved-KNG1 HC (K380) Polyclonal Antibody

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