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Anti-Human Cleaved-KLK8 (V33) Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA02140
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from the N-terminal region of human KLK8
Specificity Isoform 1 is predominantly expressed in the pancreas. Isoform 2 is expressed in adult brain and hippocampus. Isoform 1 and isoform 2 are found in fetal brain and placenta. Detected in salivary gland, uterus, thymus, breast, testis and kidney but not in spleen, liver, lung or normal ovarian tissue. Displays an 11.5-fold increase in Alzheimer disease hippocampus compared to controls and is overexpressed in some ovarian carcinomas. Expressed at low levels in normal skin while high levels are found in psoriasis vulgaris, seborrheic keratosis, lichen planus and squamous cell carcinoma skin samples. Expressed in the keratinocytes.
Isotype IgG
Reacitivity Human
Clone
Uniprot O60259
Concentration 1mg/mL
Dilution WB 1:500-1:2000, ELISA 1:10000
Formulation
Application WB,ELISA
Other Names Brain serine protease 1,BSP1,hK8,HNP,HPN,Kallikrein 8 (neuropsin/ovasin),Kallikrein related peptidase 8,Kallikrein-8,Kallikrein8,KLK 8,Klk8,KLK8 protein type 1,KLK8 protein type 2,KLK8,Neuropsin,neuropsin type 1,Neuropsin type 1,included,Neuropsin type 2,Neuropsin type 2,included,Neuropsin,mouse,homolog of,NP,NRPN,Ovasin,PRO322,Protease serine 19,PRSS 19,PRSS19,Serine protease 19,Serine protease kallikrein,Serine protease kallikrein/ovasin/neuropsin,Serine protease TADG 14,Serine protease TADG-14,Serine protease TADG14,TADG 14,TADG14,Tumor associated differentially expressed gene 14,Tumor associated differentially expressed gene 14 protein,Tumor-associated differentially expressed gene 14 protein,UNQ283
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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