Anti-Human Cleaved-CASP1 (D210) Polyclonal Antibody

Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA02101
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from the Internal region of human Caspase-1
Specificity Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.
Isotype IgG
Reacitivity Human
Clone
Uniprot P29466
Concentration 1mg/mL
Dilution WB 1:500-2000, IHC 1:50-300, IF 1:50-300
Formulation
Application WB,IHC-p,IF,ELISA
Other Names CASP-1,CASP1,CASP1,Caspase 1,Caspase-1 subunit p10,ICE,IL-1 beta-converting enzyme,IL-1BC,IL1 beta converting enzyme,IL1B convertase,Interleukin 1 beta convertase,Interleukin 1B converting enzyme,Interleukin-1 beta convertase,Interleukin-1 beta-converting enzyme,p45
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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