Anti-Human CD161 Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]

Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.

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Data Sheet	Click for Datasheet
Catalog Number	PA06417
Size	100μl
Host Type	Rabbit
Immunogen	Synthesized peptide derived from the Internal region of human CD161.
Specificity	Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype.
Isotype	IgG
Reacitivity	Human
Clone
Uniprot	Q12918
Concentration	1mg/mL
Dilution	WB 1:500-1:2000, ELISA 1:20000
Formulation
Application	WB,ELISA
Other Names	C-type lectin domain family 5 member B,CD161,CLEC5B,HNKR-P1a,Killer Cell Lectin like Receptor Subfamily B Member 1,Killer cell lectin-like receptor subfamily B member 1,KLRB1,KLRB1,Natural killer cell surface protein P1A,NKR,NKR P1,NKR-P1A,NKRP1,NKRP1A
Storage	Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript	For research use only, not for use in diagnostic procedures.

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Anti-Human CD161 Polyclonal Antibody

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