Anti-Human CCNE2 Polyclonal Antibody

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA11047
Size 100μl
Host Type Rabbit
Immunogen Synthetic peptide of human CCNE2
Specificity According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor-derived cells compared to non-transformed proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. According to PubMed:9840943 highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon.
Isotype IgG
Reacitivity Human
Clone
Uniprot O96020
Concentration 0.5 mg/mL
Dilution IHC 1:50-1:200
Formulation
Application IHC,ELISA
Other Names CCN E2,CCNE 2,CCNE2,CCNE2 protein,CYC E2,CYCE 2,CYCE2,CyclinE2,G1/S specific cyclin E2
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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