Anti-Human CASP14 Polyclonal Antibody

Believed to be a non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and cornification. Probably regulates maturation of the epidermis by proteolytically processing filaggrin.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA02117
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from the Internal region of human Caspase-14
Specificity Expressed in keratinocytes of adult skin suprabasal layers (from spinous layers to the stratum granulosum and stratum corneum) (at protein level). Expressed in keratinocytes of hair shaft and sebaceous glands (at protein level). In psoriatic skin only expressed at very low levels.
Isotype IgG
Reacitivity Human
Clone
Uniprot P31944
Concentration 1mg/mL
Dilution WB 1:500-1:2000, ELISA 1:40000
Formulation
Application WB,ELISA
Other Names Apoptosis related cysteine protease,CASP 14,CASP-14,CASP14,Caspase 14 apoptosis related cysteine protease,Caspase 14 precursor,Caspase-14 subunit p10,Caspase14,CASPE,MGC119078,MGC119079,MICE,Mini ICE
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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