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Anti-Human CASP10 B/C Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-AMC and Asp-Glu-Val-Asp-AMC.Isoform C is proteolytically inactive.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA02452
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from the C-terminal region of human Caspase-10 B/C
Specificity Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.
Isotype IgG
Reacitivity Human
Clone
Uniprot
Concentration 1mg/mL
Dilution WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:10000
Formulation
Application WB,IHC-p,IF,ELISA
Other Names ALPS2,apoptotic protease Mch-4,CASP-10,CASPA,caspase-10,FADD-like ICE2,FAS-associated death domain protein interleukin-1B-convert
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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