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Anti-Human c-FLIP Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA06307
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from the N-terminal region of human c-FLIP.
Specificity Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.
Isotype IgG
Reacitivity Human
Clone
Uniprot O15519
Concentration 1mg/mL
Dilution WB 1:500-1:2000, ELISA 1:20000
Formulation
Application WB,ELISA
Other Names c FLIP,c FLIPL,c FLIPR,c FLIPS,c-FLIP,c-FLIPL,c-FLIPR,c-FLIPS,CASH,CASP8 and FADD like apoptosis regulator,CASP8 and FADD-like apoptosis regulator subunit p12,CASP8AP1,Caspase homolog,Caspase like apoptosis regulatory protein,Caspase related inducer of apoptosis,Caspase-eight-related protein,Caspase-like apoptosis regulatory protein,Casper,Cellular FLICE-like inhibitory protein,CFLA,Cflar,CFLAR,CLARP,FADD like anti apoptotic molecule,FADD-like antiapoptotic molecule 1,FLAME,FLAME-1,FLAME1,FLIP,I FLICE,I-FLICE,Inhibitor of FLICE,MACH-related inducer of toxicity,MRIT,OTTHUMP00000163715,OTTHUMP00000206475,OTTHUMP00000206476,OTTHUMP00000206478,OTTHUMP00000206479,OTTHUMP00000206480,OTTHUMP00000206482,OTTHUMP00000207360,Usurpin,Usurpin beta
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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