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Anti-Human AKAP5 Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA03088
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from the N-terminal region of human AKAP 79
Specificity Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary.
Isotype IgG
Reacitivity Human
Clone
Uniprot P24588
Concentration 1mg/mL
Dilution WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:10000
Formulation
Application WB,IHC-p,IF,ELISA
Other Names A kinase (PRKA) anchor protein 5,A kinase anchor protein 5,A kinase anchor protein 79kDa,A kinase anchoring protein 75/79,A-kinase anchor protein 5,A-kinase anchor protein 79 kDa,AKAP 5,AKAP 75,AKAP 79,AKAP-5,Akap5,AKAP5,AKAP75,AKAP79,cAMP dependent protein kinase regulatory subunit II high affinity binding protein,cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein,H21
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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