Anti-APP (Phosphorylated) Rabbit IgG Affinity Purify

Amyloid precursor protein (APP) is precursor protein of Amyloid β which is major constituent of senile plaque in Alzheimer’s disease. It is known that there are three major isoforms, APP695, APP751 and APP770, and are generated from alternative splicing of common precursor mRNA (ref.1). Processing of APP occurs by two major pathways, non-amyloidogenic pathway and amyloidogenic pathway.The non-amyloidogenic pathway is mediated by α- and γ-secretases and gives rise to a large fragment known as soluble APPα(sAPPα) and a small 3 kDa peptide known as p3. On the other hand, the Amyloidogenic pathway is mediated byβ- andγ- secretases and yields soluble APPβ (sAPPβ) and Amyloid β. APP is expressed at many of tissue within an organism. It is supposed that the function of APP in neuron system is different from that in other organ.In nerve cells, APP containing an N- or O-type sugar chain modification (mature APP) is phosphorylated at the Thr668 position (APP695) by the actions of Cdk5 and c-Jun NH2-terminal kinase (JNK), which are nerve-specifically activated, and becomes translocated to the cell membrane and neuritis (ref. 2-4). It has been considered that the phosphorylation induces structural changes in the cytoplasmic domain of APP and influences Aβ production (ref.5-6). Regulation of the bonding of APP with FE65 is believed to be involved in information transmission (ref. 6).
List Price: $492
  • Buy 5 for $467.4 each and save 5%
  • Buy 21 for $442.8 each and save 10%
  • Buy 31 for $418.2 each and save 15%
  • Buy 51 for

Properties

Data Sheet Click for Datasheet
Catalog Number PA01060
Size 100 μg
Host Type Rabbit
Immunogen Synthetic peptide of Phosphorylated part of APP (DAAVpTPEE)
Specificity Reacts with human and mouse, and not reacts with nonphosphorylated APP.
Isotype
Reacitivity
Clone
Uniprot
Concentration
Dilution
Formulation Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
Application WB, Immuno-precipitation.
Other Names
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

© Copyright 2024 TZYBIOTECH. All Rights Reserved. SiteMap