Amyloid Beta ( 1-42 ) Aβ Anti-Human Rabbit IgG Affinity Purify

Alzheimer’s Disease (AD) is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs) in the brain. The major protein components of these plaques are beta amyloid peptide (Aβ), 40, 42 or 43 amino acid residues peptide cleaved from amyloid precursor protein by β-secretase and γ-secretase. Increased release of Aβ42 or Aβ43, which have a greater tendency to aggregate than Aβ40, occurs in individuals expressing certain genetic mutations ApoE alleles or may involve other undiscovered factors. Many researchers theorize that increased release of Aβ42/Aβ43 leads to the abnormal deposition of Aβ and the associated neurotoxicity in the brains of affected individuals.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA01043
Size 5 µg
Host Type Rabbit
Immunogen Synthetic peptide of a C-terminal part of Human Amyloidβ42.
Specificity Human Amyloid Beta Aβ 42 specific. Not cross-react with Human Amyloid Beta Aβ 40 or 43.
Isotype
Reacitivity Human
Clone
Uniprot
Concentration
Dilution
Formulation Lyophilized product in PBS containing 1 % BSA and 0.05 % NaN3.
Application IHC, WB.
Other Names Aβ, Amyloid beta, A-beta.
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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