Recombinant Human Transforming Growth Factor-beta Receptor Type II Protein

Categories: [Proteins / Peptides]
TGFBR2 is a single-pass type I membrane protein and contains one protein kinase domain. TGFBR2 exsits as a heterodimeric complex with another receptor protein and binds TGF-beta. Signals triggered through the TGF-beta receptor complex prompt various responses by the cell. One such response is to inhibit cell growth and division. Based on this action, the TGF-beta receptor type 2 is sometimes called a tumor suppressor. Defects in TGFBR2 have been associated with Marfan syndrome, Loeys-Deitz aortic aneurysm syndrome, Osler-Weber-Rendu syndrome and the development of various types of tumors.
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Properties

Data Sheet Click for Datasheet
Catalog Number TP05508
Size 20ug,50ug,100ug…
Host Human Cells
Accession P37173
Molecular Weight 42.6 kDa
AP_Mol_Weight 59 kDa
Tag C-Fc
Sequences Thr 23-Asp159
Purity > 95% by HPLC
Concentration
Formulation PBS
Other Names TGF-beta receptor type-2; TGF-beta type II receptor;TGFBR2; Transforming growth factor-beta receptor type II
Bioactivity Measured by its ability to inhibit TGF-beta1 activity on Mv-1-lu mink lung epithelial cells. The ED50 for this effect is typically 0.2-3.0 μg/ml in the presence of 1 ng/mL of recombinant human TGF-beta1.
Storage Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Postscript For research use only, not for use in diagnostic procedures.

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