Claudin-8 (C) Anti-Mouse Rabbit IgG Affinity Purify

The tight junction is identified as a belt-like region in which two lipid-apposing membranes lie close together (tight junction strands). Tight junction strands of the adjacent cells form tightly connected pairs. The proteins involved in the formation of tight junctions are divided into two categories: 1) integral membrane proteins, such as occludin, claudin and junctional adhesion molecule, JAM and 2) peripheral membrane proteins (cytoplasmic plaque proteins), MAGUK (membrane-associated guanylate kinase) homologue proteins, such as ZO-1, 2, 3, cingulin, symplekin, 19B1, and AF-6. In human, the claudin superfamily consists of at least 18 members, which are involved on paracellular transport as structural and functional components of tight junction. Claudins are directly associated with ZO-1, 2 and 3 and indirectly with AF-6 and cingulin.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA01110
Size 100 μg
Host Type Rabbit
Immunogen Synthetic peptide of part of C terminal of Mouse Claudin-8 (SFHAEKRSPSIYSKSQY)
Specificity Claudin-8 specific. Not cross reacts with Claudin-1, -2, -3, -4, -5, -6, -7, -12 and –15. (This confirmed by western blotting using each transfectants)
Isotype
Reacitivity Mouse
Clone
Uniprot
Concentration
Dilution
Formulation Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
Application IHC, WB.
Other Names
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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