CD46 Monoclonal Antibody (Clone AT2G9)

Categories: [ Antibodies][ Monoclonal Antibodies]

Membrane Cofactor Protein (CD46) is a type 1 membrane protein that plays an important inhibitory role in the complement system. CD46 regulates the complement cascade by inhibiting C3b and C4b deposited on self tissue. This protein is a cofactor that binds to C3b and C4b, allowing their degradation by a plasma serine protease called factor I. This function resides in the complement control protein repeats (CCPs), with CCP1-4 essential for regulation. CD46 is implicated in the development and/or progression of selected cancer types.

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Properties

Data Sheet	Click for Datasheet
Catalog Number	MA01162
Size	100 µL
Host Type	Mouse
Immunogen	Recombinant human CD46 (35-313aa) purified from E. coli
Specificity
Isotype	IgG2a, k
Reacitivity	Human
Clone	Anti-human CD46 mAb, clone AT2G9, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human CD46 protein.
Uniprot
Concentration	1 mg/mL
Dilution
Formulation	Liquid. In Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol.
Application	ELISA, WB.
Other Names	Membrane cofactor protein isoform 14, AHuS2, MCP, MIC10, TLX, TRA2.10.
Storage	Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript	For research use only, not for use in diagnostic procedures.

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CD46 Monoclonal Antibody (Clone AT2G9)

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