c-MPL/TPOR (AMM2) Anti-Mouse Rat IgG MoAb

Thrombopoietin promotes the growth and differentiation (proliferation) of megakaryocytes which produce platelets. TPOR (Thrombopoietin receptor), which is also called c-MPL (Myeloproliferative leukemia protein) or CD110, is a receptor for thrombopoietin. And it is suggested that TPOR may also play a role in the maintenance of hematopoietic stem cells, which are stem cells located within the bone marrow that have the potential to develop into red blood cells, white blood cells, megakaryocytes and platelets. This receptor is activated when thrombopoietin protein binds to it, and the activated receptor stimulates a signaling pathway called the JAK/STAT pathway, which transmits signals from outside the cell to the cell's nucleus and is important for controlling the production of blood cells. This antibody specifically reacts with mouse c-MPL/TPOR protein, and has neutralization activity to the reaction with thrombopoietin ligand (ref. 5).
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Properties

Data Sheet Click for Datasheet
Catalog Number MA01128
Size 100 μg
Host Type Rat
Immunogen Recombinant protein of mouse c-MPL extracellular domain
Specificity
Isotype IgG1
Reacitivity Mouse
Clone AMM2
Uniprot
Concentration Please see datasheet.
Dilution
Formulation Lyophilized product in PBS containing 1 % BSA and 0.05 % NaN3
Application WB, immuno-precipitation, flow cytometry.
Other Names
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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